COVID19 Solution : Role of Furin Cleavage Sites in Bat Coronaviruses
by Ashish Kalra BS(University of Texas, Austin), Masters(Cornell University), MBA(University of Chicago) The Current Pandemic has been devastating, killing over 4.7 million Humans globally. The Virus has come from an A...
by Ashish Kalra BS(University of Texas, Austin), Masters(Cornell University), MBA(University of Chicago) The Current Pandemic has been devastating, killing over 4.7 million Humans globally. The Virus has come from an Animal Host (Bat infected). Why not from a Lab ? Most important is #1 rated Biologist, Kristian Andersen who concludes, "Virus must have arisen by natural selection, not manipulation". In "Nature", 2020, Anderson summarizes, that the SARS2 Spike Protein is not of the calculated best design, and hence it cannot be "manipulated". It has a "natural origin".The symptoms of " "acute respiratory syndrome" are exactly identical to SARS (Civets) & MERS(Camels) ; Deadly Viruses in 2002(SARS) & 2012 (MERS) which Mankind has ignored.
After a careful study of Animal Viruses that have occurred over the last 100 years, I have reconfirmed backed by scientific evidence that Bat Coronaviruses (as shown below) have caused the Hendra Virus (Horses), Nipah Virus (Pigs),Ebola (Bats), MERS (Camels), SARS (Civets) &now COVID19 (Pangolin/Badgers). Please refer tomy recent Book, "The Killer Bat", Kalra, 2021 for better understanding of the above. These Viruses are then transmitted to Humans, when Humans consume these Bat infected Animals. Examples of this are the Asian Flu Pandemic (1957-58),caused by Human Consumption of Ducks (Source : CDC) when over 1.1 million people were killed, the Deadly SARS Virus (Human consumption of Civets, 2002, China : Source : Roos, " Nature 2020"). The Civet is a 4 legged Mammal found in China. Similar dynamics played out with the MERS Virus.
Same with the MERS Virus (Human Consumption of Camels; Source : WHO & CDC), which originated in Saudi Arabia in 2012 and spread to 32 Countries. Here also the Virus originated in Bats, and spread to Camels. This was passed onto Humans on Human Consumption of Camels. The spread and pathogenesis of COVID19 is very similar and nearly identical to that in SARS. Different Animal compared to SARS(Pangolin/Badger ; Source : Page, Hinshaw, WSJ Feb 21) this time. Same conclusion. At the heart of these Bat Coronaviruses is a "Furin Cleavage site" which is present in all Coronaviruses (Wao, Zhang : Stem Cell Medicine,2020) , which activates a protease enzyme called "furin" which hijacks a protein in Human cells.
"THE FURIN CLEAVAGE SITE" This is by Design. The Furin Cleavage site is key in "amplification of the virus". SARS-COV2 has a polybasic insertion (PRRAR) at the S1/S2 cleavage site that can be "cleaved by furin". Sequence alignment of the S1/S2 region in SARS & MERSare closely related to SARS-COV2 (Zhou, Nature, 579, 270-273). Similarly, an analogous "cleavage motif" was present at the S1/S2 of the Spike protein for MERS(Camels) (Weber, Scientific Reports 16597). Same furin cleavage site action in the case of the Nipah Virus (Bat infected Pigs) as well. NiV has appeared almost annually in Bangladesh and India with a high mortality rate (60-70%) (Infez Med (2019, Ochani, Batra). Similar for the Hendra Virus (Horses). This "Furin Cleavage site acts" when Humans eat these respective Animals.This "Furin" hijacks the protein in Human Cells, multiplies and causes "acute respiratory syndrome" in many cases and ultimately death in Human Beings. These Furin Cleavage sites are designed to "amplify" the virus' high infectivity, and becomes deadly when Humans consume these Animals. Bat Coronaviruses cause these Furin Cleavage sites in various Animals to protect them from Human Consumption. This is by Design. Humans are not meant to be eating Animals.
Further and importantly, these Bat Coronaviruses also spread to Domestically reared Animals like Cattle, Pigs and Chicken (Stanley Perlman & Anthony Fehr, PMID 25720466) (please refer to graph above). They cause "fatal" diseases like Entiritis in Cattle & Pigs, Respiratory diseases in Chicken, which get transferred to Humans on consumption &and can lead to Death in Human Beings.In "Clash of 2 Ecosystems" (Times of India, Kalra, Aug 2).I illustrate the mechanics of [(Animal-Human) + (Human-Human)raise to N transmission] with illustrations from The Asian Flu Pandemic (Ducks, 1958), SARS (Civets, 2002); MERS (Camels, 2012) and now COVID19 (Pangolin/Badgers).Bat Coronaviruses play an important role in "protecting the Animal Kingdom" from encroachment by Human Beings. In a nut shell, Humans are not designed to eat Animals. Furthermore, Animals are able to absorb these Bat Coronaviruses. Humans cannot ! Just like when Cannibals eat Human Beings, they get Brain Disease. Same for Humans and Animals. Bats play an important role in drawing the "necessary line of demarcation" between the Animal and Human Ecosystem. Net net, Humans cannot encroach on the Animal Ecosystem.
WHY PLANT BASED DIETS ARE CRITICAL ? In a fabulous book, "Preventing and Reversing Heart Disease", Dr Caldwell Esselstyn outlines the tremendous advantages of adoption of a "Plant Based Diet". He highlights that "Plant based nutrition" has a HUGE BENEFICIAL IMPACT on Endothelial cells (metabolic dynamos) that produce Nitric Oxide. "Nitric Oxide is ABSOLUTELY ESSENTIAL TO Vascular Health".
" This Nitric Oxide Chemistry explains what is perhaps the key mechanism through which my patients became heart attack proof beyond twenty years. "Their Plant based diet" reduced or entirely eliminated all the above cardiovascular risk factors. The more compliant the patient, the more he or she reduced the risks." - Dr Caldwell Esselstyn, "Preventing Heart Disease" (Page 43) Dr Esselstyn's world class research on the criticality of a Plant Based Diet in arresting all forms of "Coronary Disease" (Book: "Preventing and Reversing Heart Disease"). There is a science behind it. A Plant based Diet induce the Endothelial Cells to produce Nitric Oxide (1998 Nobel prize awarded to Furchgott, Murad) which is critical in preventing Cardiovascular Disease.The essential building block for Nitric Oxide Production is a substance called L-arginine, an amino acid that is rich in a variety of plant foods(legumes, beans & nuts (Pg 41,42).This is KEY among other things. Also frequent citations of cases of Colorectal Cancer being directly caused by "Red Meat consumption" (Source: MedXpress, 2020) are reinforcements not to eat "red meat" in particular. Also, consumption of Red Meat increases risk of Colon Cancer by 28%, and a high consumption of processed meat increases risk by 20% (Source : Harvard Health, Jan 1, 2008) The Human Body is Designed to be "Vegetarian". Finally, what we have to bear in mind is that Human Beings are designed to be "Vegetarian", and not Carnivores. Human Beings do not have Canine teeth like Carnivores to tear flesh, have much smaller kidneys than Carnivores; larger kidneys to flush out poisonous meat. Human Beings have much larger intestines like Herbivores, unlike Carnivores which have much smaller intestines. Carnivores have high levels of hydrochloric acid to digest meat. Herbivores have much lower levels. Net net, The Design of Human Beings is "Vegetarian".To conclude, the "Furin cleavage site" facilitated by Bat Coronaviruses ensures and protects Animals from Human Consumption. The Panacea to get out of this Pandemic and to prevent Future Pandemics is to "Disrupt the Animal Food Chain". Islands like Samoa & Salomon Islands which follow mainly Vegetarian Diets are an important reinforcement of a Zero Covid regime.
A Tipping Point is when a "series of negative actions act together". Pandemic 2020 is this Tipping Point. Human Beings have to change. These Pandemics as painful as they are are designed to provide the necessary catalyst for change. The "Animal Food Chain will have to be disrupted". We will have to adopt a "Plant Based Diet and Lab Based Meat Diet" (3 year migration path; protein requirement) to solve this Pandemic and prevent Future Pandemics from taking place. Period.
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