The global reservation system that is the backbone of the airlines globally says it has terminated its distribution agreement with Russia’s government-owned carrier, which could significantly affect domestic travel, reported CNN.

On Thursday, Sabre Corporation, a leading software and technology company in the travel industry announced that it has terminated its distribution agreement with Russia’s largest state-owned carrier, Aeroflot.

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Sabre is taking immediate steps to remove Aeroflot flight content from its global distribution system (GDS). It is a marketplace used by travel websites, travel agencies and corporations across the world to shop, book and service flight reservations.

Headquartered in Southlake, Texas, USA, Sabre provides its services in more than 160 countries around the world.

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Sabre has been closely monitoring the evolving situation in Ukraine with increasing concern. The primary focus has been on the safety of team members in the impacted area, as well as helping to support the relief efforts, said Sean Menke, CEO of Sabre.

“We are taking a stand against this military conflict. We are complying and will continue to comply, with sanctions imposed against Russia. In addition, today we announced that Sabre has terminated its distribution agreement with Aeroflot, removing its content from our GDS,” he added.

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The termination is the latest significant measure against the Russian aviation industry after the Western nations blocked airspace to Russian aircraft. Earlier this week, Airbus and Boeing announced that they would no longer do business with Russian customers. Both companies stopped supplying parts and support to Russian Airlines.

Delta Air Lines also suspended its codeshare booking agreement with Aeroflot.

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In response to Ukraine-related sanctions, Russia banned airlines from 36 nations from its airspace on Monday. The 36 countries include 27 members of the European Union. As Russia is the largest country in the world, the airspace ban will hit planes flying to Asia from Europe, thus forcing them to adopt alternative routes.