In the second leg of the Round of 32 tie with Real Sociedad, Bruno Fernandes is set to don the armband for Manchester United at Old Trafford on Thursday.
The Red Devils, under boss Ole Gunnar Solskjaer, will lineup in the traditional 4-2-3-1 formation, with Fred and Nemanja Matic playing as the double pivot.
United are already 4-0 ahead after the first leg and has one foot in the last 16 stages of the competition.
Real Sociedad have a real task in their hand if they are to overcome the seemingly impossible climb. La Real coach Imanol Alguacil have fielded a strong starting XI, however, winger Portu is set to start from the bench.
Former prodigal son of the Old Trafford Adnan Januzaj will make his return to the 'Theatre of Dreams'.
Manchester United (4-2-3-1)
Dean Henderson, Aaron Wan-Bissaka, Eric Bailly, Victor Lindelof, Alex Telles, Fred, Nemanja Matic, Mason Greenwood, Bruno Fernandes (C), Daniel James, Anthony Martial.
Coach: Ole Gunnar Solskjaer
Real Sociedad (4-3-3)
Alex Remiro, Andoni Gorosabel, Igor Zubeldia, Modibo, Sagnan, Aihen Munoz, Martin Zubimendi, Ander Guevara, Mikel Merino, Adnan Januzaj, Alexander Isak, Mikel Oyarazabal.
Coach: Imanol Algaucil