The third phase human trial of India’s indigenous vaccine against COVID-19, COVAXIN, will start at a private hospital in Bhubaneshwar soon, PTI reported quoting an official.

Dr E Venkata Rao, principal investigator in the COVAXIN human trial and professor in the department of Community Medicine at the Institute of Medical Sciences and SUM Hospital of Bhubaneshwar, told PTI on Sunday that the search for an effective vaccine against the coronavirus is almost at its final stage.

The IMS and SUM Hospital is among the 21 medical institutes selected across the country by the Indian Council for Medical Research (ICMR) where the third phase trial would be conducted.

The Central Drugs Standard Control Organisation (CDSCO) had recently given its nod to the third phase human trials of the indigenous vaccine, which is being developed by ICMR and Bharat Biotech.

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After completion of the first and second phase of the trial with demonstrable safety profile and immunogenicity, the large-scale efficacy trial involving thousands of volunteers has been planned now, Dr Rao said.

Dr Rao, who is the head of the Preventive and Therapeutic Clinical Trial Unit (PTCTU), said during this phase the age limit and eligibility/screening criteria would be relaxed and several volunteers who are otherwise apparently healthy would be recruited for the trial.

Like the previous phases, half of the volunteers would receive placebo and the remaining half would be administered COVAXIN in this phase. Even health care workers would be recruited for the trial. The volunteers would be followed up over a considerable period of time to look at the efficacy of the vaccine in preventing the development of the Corona disease, he said.

Rao said there had been a huge response and enthusiasm among people who had offered themselves to be volunteers for the trial. He said persons above 18 years will be taken for the human trial.

The interested volunteers for the project could enroll themselves for the trial by registering online at www.ptctu.soa.ac under the section register for clinical trials, he said.