Sorrow for the dead and dying, fear of more infections to come and hopes for an end to the coronavirus pandemic were — again — the bittersweet cocktail with which the world said good riddance to 2021 and ushered in 2022.

New Year’s Eve, which used to be celebrated globally with a free-spirited wildness, felt instead like a case of deja vu, with the fast-spreading omicron variant again filling hospitals.

Also read: Australia welcomes New Year 2022 with fireworks at Sydney Harbour. Watch

At the La Timone hospital in the southern French city of Marseille, Dr. Fouad Bouzana could only sigh when asked what 2022 might bring.

“It’s starting to become exhausting,” he said, “because the waves come one after another.”

The mostly muted New Year’s Eve celebrations around the world ushered in the fourth calendar year framed by the global pandemic. More than 285 million people have been infected by the coronavirus worldwide since late 2019 and more than 5 million have died.

Also read: Israel ‘leads the way’ with 4th dose of COVID vaccine for vulnerable

In Paris, officials canceled the fireworks amid surging infections and reintroduced mandatory mask-wearing outdoors, an obligation followed by the majority of people who milled about on the Champs-Elysées as the final hours of 2021 ticked away.

In Berlin, police urged people not to gather near the Brandenburg Gate, where a concert was staged without a live audience. In Madrid, authorities allowed only 7,000 people into the city’s Puerta del Sol downtown square, a venue traditionally hosting some 20,000 revelers.

In the United States, officials took a mixed approach to the year-end revelry: nixing the audience at a countdown concert in Los Angeles, scaling it back in New York yet going full speed ahead in Las Vegas, where 300,000 people were expected for a fireworks show on the strip.

Also read: ‘Surge will be so fast’: WHO’s Soumya Swaminathan warns amid omicron scare

President Joe Biden noted the losses and uncertainty caused by the pandemic but said: “We’re persevering. We’re recovering.”

“Back to work. Back to school. Back to joy,” Biden said in a video posted on Twitter. “That’s how we made it through this year. And how we’ll embrace the next. Together.”

In New York, officials planned to allow just 15,000 people — vaccinated and masked — inside the perimeter around Times Square, a sliver of the 1 million that typically squeeze in to watch the famed ball drop. Outgoing Mayor Bill de Blasio, defending the event, said people need to see that New York is open for business.

Also read: Vladimir Putin wishes Russians happier new year, hails their strength

Yet by Thursday, rapper LL Cool J had dropped out of the New York telecast after a positive COVID-19 test and restaurant owners battered by staffing shortages and omicron cancellations throughout the holiday season struggled to stay open.

“I’m really scared for our industry,” said New York restaurateur David Rabin, who watched reservations and party bookings disappear this month. “No one made any money in December. The fact they may have a good night tonight has no impact.”

Also read: Amid omicron threat, best stay at home ideas for New Year parties

Airlines also struggled as the year came to a close, canceling thousands of flights after the virus struck flight crews and other personnel and amid bad weather.

The pandemic game-changer of 2021 — vaccinations — continued apace. Pakistan said it had fully vaccinated 70 million of its 220 million people this year and Britain said it met its goal of offering a vaccine booster shot to all adults by Friday.

In Russia, President Vladimir Putin mourned the dead, praised Russians for their strength in difficult times and soberly warned that the pandemic “isn’t retreating yet.” Russia’s virus task force has reported 308,860 COVID-19 deaths but its state statistics agency says the death toll has been more than double that.

Also read: Surging COVID cases in metro cities indicator of India’s 3rd wave? Explained

“I would like to express words of sincere support to all those who lost their dear ones,” Putin said in a televised address broadcast just before midnight in each of Russia’s 11 time zones.

Elsewhere, the venue that many chose for New Year’s celebrations was the same place they became overly familiar with during lockdowns: their homes.

Pope Francis also canceled his New Year’s Eve tradition of visiting the life-sized manger set up in St. Peter’s Square, again to avoid a crowd. In an unusual move for Francis, the 85-year-old pontiff donned a surgical mask for a Vespers service of prayer and hymns Friday evening as he sat in an armchair. But he also delivered a homily standing and unmasked.