Manchester City and Everton fixture at Goodison Park on Monday was postponed after the former club reported of more COVID-19 cases in the team, adding more to the four it earlier found on Christmas, an ESPN report said.
City also confirmed their players will be off the training ground for an “indeterminate period” till they go through a thorough testing and considered fit to play.
"Manchester City FC can confirm that this evening's Premier League fixture at Everton has been postponed, the club said in a statement, reported by ESPN.
"After the latest round of COVID-19 testing, the club returned a number of positive cases, in addition to the four already reported on Christmas Day.
"With the security of the bubble compromised, there posed a risk that the virus could spread further amongst the squad, the staff and potentially beyond,” it said.
"Based on strong medical advice the Premier League, in consultation with both clubs, have decided to postpone the fixture."
Gabriel Jesus and Kyle Walker, along with two other staff members from the club, were found infected with coronavirus on Christmas.
City has requested the Premier League to rearrange the game on a later date, which the League confirmed it will in a statement.
"Manchester City lodged a request with the Premier League today to rearrange the game following an increase in positive COVID-19 test results received by the club this morning, on top of the cases reported on Christmas Day.
"This rise has created uncertainty and the Premier League Board received medical advice that the match should be postponed. The Board agreed to rearrange the game as a precaution, and further testing will now take place tomorrow,” it said in a statement.
"The decision has been taken with the health of players and staff the priority.
"The Premier League continues to have full confidence in its protocols and rules, and the way in which all clubs are implementing them.
"The League wishes those with COVID-19 a safe and speedy recovery and will rearrange the postponed fixture against Everton in due course."
Carlo Ancelotti's Everton are third in the league while City, managed by Pep Guardiola, are in sixth, trailing the Toffees by three points.
The postponement is the second this season after an outbreak at Newcastle United forced the league to call off their match at Aston Villa this month.
City are scheduled to play Chelsea next on January 3 at Stamford Bridge while Everton are due to face West Ham on January 1.