Nicholas John Bosa is an American football defensive end for the San Francisco 49ers of the National Football League (NFL). He played college football at Ohio State and was selected second overall by the 49ers in the 2019 NFL Draft.

Bosa was named NFL Defensive Rookie of the Year by having nine sacks and helping the team reach Super Bowl LIV. He is the son of John Bosa and the brother of Joey, both of whom also played in the NFL.

Bosa was reportedly projected to be the first overall pick in the draft by a majority of analysts and scouts. He received an invitation to the NFL Scouting Combine as one of the top prospects at the draft.

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Except for the 10 yard and 20 yard split, Bosa completed all of the required combine drills and positional drills. Bosa met and interviewed with 8 NFL teams at the combine, including the Arizona Cardinals, San Francisco 49ers, New York Jets, New York Giants, and Tampa Bay Buccaneers.

A week before the draft, he was criticized for his political beliefs and controversial tweets, such as calling Colin Kaepernick a “clown”, expressing support for US president Donald Trump, and “liking” a post on Instagram that included racial and homophobic slurs as hashtags.

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During Week 2 in the 2020 season against the New York Jets, Bosa suffered a torn ACL and was ruled out for the rest of the season. He was placed on injured reserve on September 23, 2020.

Joey Bosa, his brother, also played college football at Ohio State before being selected third overall by the San Diego Chargers in the 2016 NFL Draft.

Their father, John Bosa, was a first round pick by the Miami Dolphins in the 1987 NFL Draft out of Boston College. His uncle Eric Kumerow, and cousin Jake Kumerow have also played in the NFL.

His grand-uncle, Mike Pyle, also played in the NFL. He is the great-grandson of former Chicago Outfit leader Tony Accardo.