Buffalo Bills

The Bills boast the best defense in the league’s 2021 season so far with the lowest passer-rating of 60.7, fewest yards per play (4.3), points per game (12.8) and boasting the fifth-highest pressure rate (24.8%).

Bills’ impressive run so far only makes their Monday Night Football clash with Tennessee Titans even more interesting given their offensive line ranks 30th in PFF’s pass-blocking efficiency (78.2) with the fourth-most pressures (73) and most sacks (15) allowed.

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Arizona Cardinals

The Cardinals defense showed up big time in their Week 5 clash against the San Francisco 49ers led by Trey Lance. 

While the Arizona offense was clearly struggling it was the defense lineup that held Lance and his team to 10 points, 338 total yards and forced four turnovers on downs.

Going into Week 6, the Cardinals defense is allowing the fourth-lowest conversion rate on third downs (31.58%), the sixth-lowest passer rating (83.3) and the sixth-fewest points per game (19.0).

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Dallas Cowboys

The Cowboys are a great target for fantasy football going into Week 6 for their clash against the New England Patriots.

Their defense is playing quality football at the moment and have allowed the seventh-lowest passer rating to quarterbacks (85.0) and the 11th lowest scoring rate (34.8%), plus they have Trevon Diggs who keeps intercepting passes.

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Denver Broncos

Broncos are up against the Las Vegas Raiders in Week 6, a game which is going to be hard to predict after the Broncos’ loss to the Steelers in Week 5.

However, the Broncos defense continues to rank as one of the finest in the league this season. Put that up against a dangerous Raiders offense and you’ve got a game.

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The Broncos are ranked in the top 10 both against the run and the pass, are 11th in turnovers forced, and have been good at getting after the quarterback with 12 sacks. 

The only criticism for their defense is that the good performances have come against weaker offenses, which will be tested in Week 6.