Patrick Mahomes and Kansas City Chiefs have been left helpless after Tennessee Titans raced to a 27-3 lead at the end of the third quarter on Sunday.

Ryan Tannehill is 21 of 27 for 270 yards, while NFL rushing leader Derrick Henry has a touchdown pass against the two-time defending AFC champs late in the second quarter.

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The Titans have 259 yards and 17 first downs while Mahomes and company have 35 yards and three first downs in their first meeting since the AFC championship game during the 2019 season.

Tennessee was already up 17-0 when Mahomes was intercepted for the sixth consecutive game, the longest streak of his career. Rashaan Evans had a diving catch on a tipped ball for the ninth pick of the year for Mahomes. The 2018 MVP had six all of last season.

Titans receiver A.J. Brown has five catches for 89 yards and a 24-yard touchdown after battling food poisoning during the week.

With inputs from the Associated Press