A popular sweetener found in items like Diet Coke is about to be labeled as potentially carcinogenic, which is likely to cause a significant dispute between industry and authorities.

For the first time, aspartame is about to be classified as a probable carcinogen by the International Agency for Research on Cancer (IARC), the World Health Organization’s cancer research division, according to two persons familiar with the procedure who spoke to Reuters.

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What is the sweetener in Diet Coke?

Aspartame is a low-calorie artificial sweetener that is around 200 times sweeter than sugar and is categorized as an E number, a phrase used to describe additives in food and drink goods. Aspartame is a white, odorless powder.

The IARC decision, which was made earlier this month following a meeting of the group’s outside specialists, aims to determine whether or not anything poses a risk based on all available published information.

How much of a product a person can safely ingest is not taken into account. JECFA (the Joint WHO and Food and Agriculture Organization’s Expert group on Food Additives), a different WHO expert group on food additives, along with decisions from national regulators, provide this advise for individuals.

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Similar IARC decisions for other drugs, though, have prompted litigation, alarmed people about their use, and forced producers to rework formulas and employ alternatives. This has given rise to complaints that the public may find the IARC’s assessments perplexing.

This year, JECFA, the WHO committee on additives, is also examining the usage of aspartame. It started meeting at the end of June and is scheduled to release its conclusions on July 14—the same day the IARC makes public its verdict.

JECFA has stated since 1981 that aspartame is safe to ingest within established daily limits. For instance, a 60 kg (132 lb) adult would have to consume between 12 and 36 cans of diet soda each day, depending on the amount of aspartame in the beverage, to put themselves in danger. National regulators, including those in the United States and Europe, mostly concur with this viewpoint.

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The JECFA committee’s findings and those of the IARC were both “confidential” until July, according to an IARC spokesman, who also noted that they were “complementary,” with the IARC’s conclusion serving as “the first fundamental step to understand carcinogenicity.”

The additives committee “conducts risk assessment, which determines the likelihood that a particular type of harm (such as cancer) will occur under specific circumstances and levels of exposure.”

However, according to letters from US and Japanese officials seen by Reuters, industry and regulators worry that having both processes at about the same time may be confusing.

JECFA has stated since 1981 that aspartame is safe to ingest within established daily limits. For instance, a 60 kg (132 lb) adult would have to consume between 12 and 36 cans of diet soda each day, depending on the amount of aspartame in the beverage, to put themselves in danger. National regulators, including those in the United States and Europe, mostly concur with this viewpoint.

The JECFA committee’s findings and those of the IARC were both “confidential” until July, according to an IARC spokesman, who also noted that they were “complementary,” with the IARC’s conclusion serving as “the first fundamental step to understand carcinogenicity.” The additives committee “conducts risk assessment, which determines the likelihood that a particular type of harm (such as cancer) will occur under specific circumstances and levels of exposure.”

However, according to letters from US and Japanese officials seen by Reuters, industry and regulators worry that having both processes at about the same time may be confusing.

Mars Wrigley, Coca-Cola, and Pepsico are all members of the International Sweeteners Association, which responded angrily to the news by alleging the impending IARC verdict was based on “widely discredited research.”

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Aspartame has been investigated for a long time, and a French study released in March of last year suggested that those who take it may experience an increased chance of developing cancer.

Data analysis by specialists from the Sorbonne Paris Nord University and the French National Institute for Health and Medical Research revealed a possible elevated risk for breast cancer and obesity-related malignancies.

No such correlation was discovered in prior extensive human investigations, and UK specialists concluded that no causal link had been discovered.

Another study, released in December of the previous year, discovered a connection between anxiety in mice and the sweetener, which is present in roughly 5,000 diet goods and beverages.

According to the study, which was published in the journal PNAS, aspartame consumption caused anxiety in mice, and the effects might be passed down to up to two generations of male rats.