. New Brunswick, NJ, USA
US-based firm's single-shot COVID-19 vaccine shows promising result
Johnson and Johnson's vaccine offers a single dose protection. (Photo credit: Representative image)
- The trial included approximately 1,000 healthy adults
- The third phase trial is expected to include 60,000 people
- Moderna INC and Pfizer INC plan to introduce a two dose protection aginst the novel corona virus
As per interim results published on medical website medRxiv, Johnson and Johnson's experimental vaccine called Ad26.COV2.S can stand tall versus Moderna Inc and Pfizer Inc's work, reported Reuters.
J&J's vaccine produced a strong immune system in the early-to-mid stage clinical trial according to the results published on Friday. Owing to the Ad26.COV2.S' single shot approach against its competitors' two-dose assumption, the vaccine might simplify the distribution process.
Johnson and Johnson went public with this vaccine in July and with significant backing from the US Government, they conducted a trial on 1,000 healthy adults. The American multinational corporation expects results of their phase 3 trial by the end of the year or early next year. The phase 3 trial, involving 60,000 people, started on Wednesday.
However, certain questions pertaining to the vaccine's ability to protect the elderly population from the virus. Researchers, including those from J&J’s unit Janssen Pharmaceuticals, said 98% of participants with data available for the interim analysis had neutralising antibodies, which defend cells from pathogens, 29 days after vaccination.
The immune response results were available from only a small number of people - 15 participants - over 65 years old, limiting the interpretation.
The results, released on the medical website medRxiv, have not been peer-reviewed.
For now, the results justify why more studies are needed in larger numbers to look for serious adverse effects, Dr Barry Bloom, a professor at Harvard TH Chan School of Public Health who was not involved in the J&J trial, told Reuters.
“Overall, the vaccine is doing what you would expect it to do if you were to move it to Phase 3 trials,” Bloom said.