On Jameson Taillon's 13th pitch, Guerrero blasted his 40th home run. The slugger and his Hall of Fame father became the second father-son combo to smash 40 home runs, behind Cecil and Prince Fielder. Guerrero had three hits in the game, extending his hitting streak to 15 games, which is a career record.
In his 16-year career, Guerrero Sr. hit 449 home runs. He had a career-high of 44 with the Montreal Expos in 2000.
Meanwhile, Marcus Semien blasted a single home run in the first inning and a grand slam in the ninth for Toronto's sixth of the season. He's hit five home runs in his previous five games and has 37 for the season, which is a career-best.
The Blue Jays' Teoscar Hernández also hit a home run in the ninth inning.
The Blue Jays won for the eighth time in nine games, with to Hyun Jin Ryu's (13-8) six-inning performance. This season, Toronto has a 5-2 record in the Bronx.
After losing his previous two outings, Ryu (13-8) limited the Yankees to three singles. He struck out six batters, including Joey Gallo three times, and did not walk a single batter.
At first base, Ryu had some assistance from a slimmed-down Guerrero. Guerrero, who dropped 42 pounds over the summer, had two good stretches in which he got a throw from shortstop Bo Bichette in the fifth inning and a toss from Semien on a double play in the sixth inning.
Meanwhile, after two one-run losses to the Orioles, the Yankees have now lost seven times in their last nine games following their first 13-game winning streak since 1961.
In seven innings, Taillon (8-6) allowed three runs on three hits. Following a 15-race undefeated streak, he lost his second consecutive start.
Tim Mayza and Trevor Richards both pitched a scoreless inning. Toronto's AL-leading 14th shutout was completed by Adam Cimber, who pitched a five-hitter.
With inputs from the Associated Press